For example, pancreatic cancer is a locally lethal but not globally lethal cancer; it has a local lethality value of 0.91 but a global lethality value of 0.06 (Table 2).
A cancer with a high local lethality suggests that it has a high number of deaths within its own incidences, while its global lethality may or may not be high.
After HMGB1 was first shown to have an additional function as a late mediator of endotoxin lethality [ 14], it has since been revealed as a protein with inflammatory cytokine activity in the pathogenesis of influenza [ 32– 34], as well as in many other inflammatory diseases.
When asked how realistic the weaponization of Marburg is, Slenczka was blunt: "Biological-weapons strategists must be pretty damn desperate if they jump at something just because it has a high lethality," he said.
But even if the design is a little unworkable, it doesn't matter, as long as it has that guarantee of lethality".
While the use of synthetic lethality has been around for decades in model organism studies, it has only recently been applied to cancer therapy and judging by recent results, with great success.
It has roles in cellular proliferation, differentiation and apoptosis, with yy1 knockout mice having in utero lethality.
"Those are also key developments that indicate that it's possible, and I want to stress that it's possible, that the period of stark lethality that has been going on since 2013 may have run its course by now," Millman said.
Although reports of human-to-human HPAI H5N1 transmission are rare, its high lethality has raised considerable concern worldwide.
Although there are only rare reports of human- to-human H5N1 transmission to date, its high lethality has raised considerable concern worldwide.
