Although sharing of drugs in clinical trials correlates positively with local lethality values, however, it does not translate to increase sharing of the approved drugs for the most locally lethal cancers.
The lnkn-1 cDNA was able to rescue the gonad defect but not maternal effect lethality, possibly because it does not contain all regulatory elements for complete tissue expression or is silenced in the germline.
Although ANBR binds Cul1-4, it does not rescue the lethality of Roc1a mutation.
However, the presence of Schistosoma does not appear to modify the virulence of Pb and, consequently, it does not alter the lethality of Plasmodium infection.
The new compound was determined to be toxic in the brine shrimp lethality test, but it did not have cytotoxic activity against a variety of human cancer cell lines.
In contrast to previously published data (37), although loss of Tex19.1 was associated with embryonic lethality, this lethality did not appear to affect females more strongly than males, despite our analysis including almost 1000 genotyped pups (Supplementary Material, Table S1).
Analysis of bdnf −/− bax −/− mutants revealed that, although the Bax null mutation completely rescued cell loss in the absence of BDNF, it did not rescue the lethality of the BDNF null phenotype.
Sodium arsenite at a dose of 40 mg/L supplied via drinking water in mice significantly raised the serum level of liver function markers such as AST, ALT, and ALP, and caused arsenic deposition in liver and ROS generation, though it did not show any lethality up to 30 days of exposure.
Global lethality and local lethality do not have a significant correlation in the older FDA cancer networks.
The data described above suggest that Tek promoter-driven Ate1 deletion results in early embryonic lethality that does not depend on the functions of the endothelial cells.
