Sentence examples for lethality is unclear from inspiring English sources
While the reason for the lethality is unclear, we observed a less developed eye (4e top arrow), as a mark of developmental delay and craniofacial defects including both lateral and midline facial clefting (4e middle and bottom arrow, respectively).
Although the underlying mechanism of this lethality is unclear, histological study indicated that TANK1−/−TANK2−/− and TANK1+/− TANK2−/− embryos lacked umbilical cords and that placental development was abnormal, factors which are sufficient to result in the death of embryos.
While the reason for the observed lethality is unclear, use of the heat-shock promoter to provide a pulse of expression only in the injected animal circumvents this problem.
Although the basis of the embryonic lethality is unclear, it was hypothesized to be due to abnormal heart development or function, as the hearts of mutant embryos display greater heterogeneity in cell size and orientation (Thomas et al., 1995).
Even if one assumes that Trp53-mediated apoptosis is significantly relevant for the mechanism of Trp53 rescue of Brca1 lethality, it is unclear how this Trp53 mechanism relates to tumorigenesis due to Trp53 loss.
In higher eukaryotes, such as Drosophila, deletion of Sec61β causes lethality, but its physiological role is unclear.
However, whether the PcG/trxG system plays a role in postnatal heart is unclear, partly because the embryonic lethality of many PcG/trxG mutations precluded functional study of postnatal development.
Since TIN2 interacts with both TRF1 and TRF2 [ 11- 13], it is unclear at this point what the exact pathway to lethality is.
Much of their data are on the phenotype of the Mmp14-null mice at embryonic and early postnatal stages (due to the early lethality limiting later analysis), yet the tendon phenotype of the CKO at corresponding stages is unclear.
Precisely why is unclear.
