Sentence examples for lethality is the from inspiring English sources

Co-lethality, or synthetic lethality is the documented genetic situation where two, separately non-lethal mutations, become lethal when combined in one genome.

Consistent with these results, examination of protein derived from 3rd instar larvae from the above strains in the presence of the actinGAL4 driver revealed significant reductions in SMN expression levels (Figure 3D), further suggesting the observed lethality is the direct result of SMN protein attenuation.

Synthetic lethality is the lethality resulting when two, individually survivable, mutations, are co-present [ 14].

For many disease models, repair or restoration of tissue function, not lethality, is the translational goal.

One example of successfully targeting DNA repair for synthetic lethality is the use of poly (ADPribose poly-merase (PADPribose poly-meraseCA1/BRCA2-mutant breast cancer or ovarian cancer cells [21], [22].

A recessive model fits with a higher likelihood, (change in log-likelihood, Δℓ = +2.5 for h = 0 compared to h = 1 2 ), but fits a large negative selection coefficient s ^ ≈ − 1, which is outside the range for which our approximations are valid, but may indicate that a model of recessive lethality (or near lethality) is the best explanation for the data.

Cell viability and lethality are the two parameters which are used to measure the toxicity caused by the nanoparticles.

Synergistic interactions occur when a double-mutant has a more extreme effect on the fitness than would be expected from independent single mutants alone, and can therefore identify e.g. complementary pathways, with synthetic lethality being the extreme case (wij = 0).

Nevertheless, in all three experiments, the timing of expression of 'Type 1' and 'Type 2' lethality was the same.

E. coli causes the colibacillosis such as acute septicaemia, vitelline peritonitis, enteritis, genital diseases, and so forth, its morbidity and lethality are the highest in bacterial diseases of chicks in China [ 1, 2].

While new vaccines with fewer adverse consequences are being developed (3 ), the existing vaccines, which have potential side effects and a not negligible lethality, are the only vaccines available (4, 5 ).