Sentence examples for lethality is based from inspiring English sources

The concept of synthetic lethality is based on the reliance of cancer cells on DNA repair to maintain cell division.

The concept of synthetic lethality in cancer is based on early observations in yeast and Drosophila that have been extended to higher organisms [ 12, 13].

Understanding of BRCA1/2 interaction with the base excision repair (BER) pathway could improve therapy based on 'synthetic lethality', whose effectiveness is based on homologous recombination deficiency in cells lacking functional BRCA genes.

In conclusion, as proof-of-concept, we show that a synthetic dosage lethality screen, which is based on the toxicity induced by gene overexpression, offers an effective, complementary method to elucidating biological functions of proteolytic pathways.

We note that this classification is based on embryonic lethality after par-1 RNAi treatment alone, without a control for background levels of embryonic lethality.

A new version of targeted therapy is based on a so-called "synthetic lethality" principle 61.

One emerging class of therapeutic agents for this purpose is based on the principle of synthetic lethality.

The system is based on the transmission of a transgene combination that causes embryo-specific lethality in the progeny.

Lethality calculation was based on the expected number of mutant progeny relative to the number of control siblings from the same cross.

The more robust genetic predictions used to identify these additional DOX resistance genes are based primarily on synthetic lethality or fitness interaction data [101], [102], [55].

While doctors' prescriptions are based on more than efficacy and cost -- they must also consider potential drug interactions, lethality of the drug if overdosed, the patient's prior history and patient preference -- the abandonment of older medications by our residents cannot be justified given available data.