Sentence examples for lethality indicates that from inspiring English sources
Our finding that loss of the CTD specific kinase gene CTK1 completely suppresses BRCA1-induced lethality indicates that BRCA1 interacts preferentially with the phosphorylated elongating form of the RNAPII specified by CTDK-I (i.e. phosphorylated on Ser2 and Ser5).
This lethality indicates that polyQ toxicity is enhanced and this is confirmed by the fact that surviving adults show worsened retinal degeneration than controls.
The finding that pharmacological and genetic interruption of the JNK pathway attenuated PEITC-mediated lethality indicates that stress pathways have a critical functional role in apoptosis induction by this agent.
The inconsistency of cytotoxicity and lethality indicated that factors other than cytotoxicity may be involved in the amelioration of the lethal effect for 3 and 5 nm GNPs. Figure 6 MTT assay to obtain LC50for different sizes of GNPs using Hela cells as a model system.
Growing flies at a higher temperature resulted in higher lethality, indicating that the rt gene also contributed to normal development.
In tadpoles, its expression from a ubiquitously active promoter resulted in embryonic lethality, indicating that HSF1 signaling is required for normal Xenopus development.
Malfunction of Ptc1 in mice leads to embryonic lethality, indicating that it is an essential protein in the early development of mammals [10].
Specifically, both mutant strains of mice exhibited sternal fusions, defects in kidney development, and perinatal lethality, indicating that Hs2st and the secreted sulfatases might regulate similar developmental processes.
Substitution of the Roc1a RING domain with that of Roc1b results in a protein with similar Cullin binding properties to Roc1a that is active as an E3 ligase but cannot complement Roc1a mutant lethality, indicating that the identity of the RING domain can be an important determinant of CDL function.
This lack of lethality indicated that CDC 684 is significantly attenuated.
Curiously, the rio2 3G allele that did not recruit Crm1 in the presence of RanQLGTP in vitro, rescued the synthetic lethality, indicating that Rio23G is still functional in vivo.
