Sentence examples for lethality in which from inspiring English sources

Exploiting a phenomenon known as synthetic lethality, in which simultaneous loss of two interacting genes leads to loss of viability, aids in the investigation of these interactions.

One possibility is that in highly conserved proteins the occurrence of double mutations, as observed in recessive disease genes, is often associated with lethality, in which case a disease condition will not be observed.

Moreover, it may also be useful as a monotherapy when it achieves synthetic lethality, in which inhibition of a complementary DNA damage response pathway selectively kills cancer cells that have a defect in a particular DNA repair pathway.

The observation that tumour cells exposed to chronic hypoxia acquire defects in homologous recombination and increased sensitivity to PARP inhibition (Hegan et al, 2010) is an example of 'contextual synthetic lethality' in which hypoxia-induced repair-deficient tumour cells can be targeted by disrupting backup pathways (Chan and Bristow, 2010).

This corroborates with the synthetic lethality concept in which cells with a functional BRCA1 protein maintain their homologous recombination function and are capable of repairing the DSBs induced by the HD-PB chemotherapy, including normal tissues of BRCA1 mutation carriers that did not lose the wild-type allele.

One can likewise easily identify cases where many pairs of non-edges were in fact tested for synthetic-lethality interactions, in which cases the likelihood of ascertainment bias is greatly reduced.

Lig4 homozygous mutations result in embryonic lethality in mice which however, can be rescued by Tp53 deficiency [31].

This is consistent with a study of synthetic lethality in yeast which demonstrated that greater than 70% of the links representing epistatic relationships in a gene network following treatment with a DNA damaging agent are not present before-hand [ 45].

Expression of Notch RNAi driven by lzGal4 causes pupal lethality, however, flies in which Notch signaling is disrupted using dominant negative forms of the pathway components Psn or Su(H) survive to adulthood.

However, in contrast to sKO animals in which lethality from audiogenic seizures is in the range of 20 30%, audiogenic lethality in BC1−/− Fmr1−/− dKO animals was found approaching 90%.

By contrast, with LT challenge previously in which lethality was not evident until 48 h, treatment with HS and raxi as late as 12 h did significantly improve survival [21].