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Leptin-deficient ob/ob mice demonstrate phenotype similar to GRdim mice: a strong suppression of energy metabolism, low oxygen consumption, severe hypothermia, and increased lethality in systemic inflammation.
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Complete absence of frataxin is incompatible with life in higher organisms, as demonstrated by the embryonic lethality observed in systemic and conditional gene knock-out models (3– 6).
In contrast, recombinant VN1203 virus, in which HA was substituted with the HA of HK213, showed reduced lethality and systemic spread in mice.
It is evident from detailed experimental study that the dysregulated coagulation system that typifies the pathophysiology of septic shock contributes to systemic inflammation and lethality in sepsis.
To elucidate the role of fetuin-A in systemic inflammatory diseases, we determined the influence of fetuin-A disruption on endotoxemic and septic lethality.
However, in systemic inflammation, such as sepsis, administration of MCP-1 is protective and neutralization of MCP-1 increases lethality in response to endotoxin challenge [ 40, 41].
Esophageal manometry in systemic amyloidosis.
Autonomic neuropathy in systemic sclerosis.
Oesophageal changes in systemic sclerosis.
Cytokines in systemic lupus erythematosus.
British policing is not in systemic crisis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com