Sentence examples for lethality in primary from inspiring English sources

In fact, inhibitors of MEK1/2 or SRC signaling are known to enhance CHK1 inhibitor lethality in primary human GBM cell lines, and although the mechanism seems to be mediated by caspases, overexpression of Bcl-XL alleviates but does not completely abolish MEK1/2 and CHK1 inhibitor cytotoxicity in GBM cells.

Further, we show lethality in invasive primary tumor cell lines with inhibiting H+ efflux.

Taken together, these findings represent a novel mechanism by which agents targeting Mcl-1 potentiate BITC lethality in transformed and primary human leukemia cells and inhibitory activity of tumor growth of Jurkat xenograft model.

Taken together, these findings represent a novel mechanism by which agents targeting Akt/JNK/Mcl-1 pathway potentiate PEITC lethality in transformed and primary human leukemia cells and inhibitory activity of tumor growth of U937 xenograft model.

To directly address the mechanisms that might be contributing to the lethality in the double mutant embryos, primary aortic EC and microvascular lung EC were isolated and cultured from Erk1−/− Erk2fl/fl mice.

Significant challenges impeding the application of genomic medicine in prostate cancer include high levels of intra-tumoural heterogeneity and multifocality in primary tumours, and the often long natural history from diagnosis to metastasis or lethality.

These data strongly suggest that the primary cause of the observed growth defect and lethality in itprsv35/ug3 larvae is reduced food intake.

We observed no lethality in either cohort of mice, indicating that BM failure in Cited2Δ/Δ mice is the primary cause of mortality.

"Lethality in the virus may rely on several changes," he said.

Injection of 5 and 3 nm GNPs, however, did not induce sickness or lethality in mice.

Finally, LPS induced 60%and55%5% lethality in BDL placebo- and TZP-treated treated mice and no lethality in sham-operated mice, while only BMAP-27 significantly reduced the lethality to 10%.