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But its lethality has been used in the past to bring devastation to civilian neighborhoods, most famously by the Russians during the siege of the Chechen capital of Grozny over a decade ago, where thousands of civilians were killed and hundreds of buildings reduced to rubble.
The strategy of synthetic lethality has been validated by research and clinical trials.
This review describes how the biological concept of synthetic lethality has been successfully implemented to identify new therapeutic approaches and targets in models from yeast through to human cells.
Heterozygosity for the Ts locus can be lethal, depending on the strain used for the cross, and the locus controlling this dominant lethality has been mapped [6].
In order to better understand the regulatory mechanism as well as the functional effect of MAP, we investigated the methylation status of these genes in mice, for which embryonic lethality has been reported in Wnt2 and Ephb4 knock-outs [28], [29].
Therefore sickness of double mutants or "synthetic lethality" has been used to reveal novel gene functions.
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A lot of BDM-type hybrincompatibilitiesincludinguding hybrid sterility and hybrid lethality, have been studied, and the molecular nature of the causal genes was recently elucidated in some animal and plant species [2], [3].
Fewer than 10 cell-cycle mutants with embryonic lethality have been identified.
Our efforts to identify the cells responsible for this lethality have been unsuccessful.
Loci linked to chlorotic or albino leaf, dwarfism and lethality have been detected in strawberry and apple.
However, shRNA delivered by gene therapy vectors has raised concerns because severe toxicity and lethality have been reported in mice (Grimm et al, 2006).
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