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Local lethality has a significant correlation with clinical trial drug numbers for the cancers other than the most locally lethal ones.
We estimate that N2's high induced lethality has a dominance of 0.982 over CB4856s low induced lethality (see Materials and Methods).
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Our analyses suggest that global lethality has an affect on the number of FDA approved and clinical trial cancer drugs.
The correlation and linear regression analyses suggest that global lethality has an impact on the drug trial and approval numbers, for the cancers in this study.
We showed that local lethality has an effect on the clinical cancer drug trial sharing as well as FDA approved drug sharing, the latter appears to be a recent trend.
On the other hand, local lethality has an affect on the FDA approval and clinical trial-based drug sharing, but not on the number of FDA approved drugs and clinical drug trials.
This embryonic lethality has an effect of derepression of the transcription repressor complex c-myc-Miz1.
Overall, this analysis provides a systems level view of cancer drugs and suggests that death statistics (i.e. global vs. local lethality) have a differential impact on the number of approvals, trials and drug sharing.
Paradoxically, greater lethality has not led a trend toward greater loss of life.
Synthetic lethality has been proposed as a therapeutic strategy for treating cancer.
Although no inherited diseases are known to result from mutation of these genes, one case of neonatal lethality has been attributed to a defect in Drp1 (25).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com