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This demonstrates that our approach has broader utility and can be applied to other synthetic lethality data sets.
We demonstrate the general use of Multivariate Gaussian Mixture Modeling for selecting candidate genes for experimental characterization from synthetic lethality data sets.
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The high confidence, synexpression, gene neighborhood, synthetic lethality, gene cooccurrence, and gene fusion interactions data sets were parsed from supplementary Table 4 of [ 9].
This is the case when studying yeast pathways that have not been explored extensively by synthetic lethality screening, so that only a handful of data sets exist.
Application of the same statistical methodology on synthetic lethality data for a tor2 ts-mutant using a different set of genomic features also resulted in lists of new candidate genes potentially involved in TOR2 signaling.
Many data sets show this.
They all use the same data sets.
There are several major data sets.
Today we have 274,000 data sets available.
These unique capabilities will make it possible to obtain more flight-representative lethality data in a ballistic range.
In retrospect, Fouchier says, "we should have ignored [Science's] reviewers' request for lethality data," given the confusion that ensued.
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