Sentence examples for lethality could be from inspiring English sources
We previously described MiMIC insertions in a coding intron of three genes that had recessive lethal phenotypes and showed that the lethality could be reverted by removing the gene trap cassette by RMCE (Venken et al., 2011a).
Mice lacking RALDH3 were neonatal lethal, due to the respiratory tract obstruction in nasal region, and the neonatal lethality could be rescued by atRA supplements [ 53], suggesting that RALDH3 is an atRA synthesis enzyme.
Its lethality could be accidental — a protein good at killing sentries might just go on killing other cells once inside the fort.
Lethality could be caused by the failure or defects at any stage of reproductive development, such as reduced fertility of male and female gametes, failure of fertilization, or more likely abortion of embryo development.
Arp66BEP3640 (from Bloomigton, stock #17149) is caused by a P-element insertion 138bp upstream of the predicted start codon; its lethality could be rescued by P-element excision [45].
In this study we report that RNAi-induced lethality could be achieved by direct delivery via the exoskeleton; moreover an effective high-throughput NGS method was used to select stage-specific RNAi target genes in the Asian corn borer.
Failures in placental development, cell migration, or hematopoietic proliferation at this embryonic stage are also common reasons for embryonic lethality and could be the cause of lethality in the Ctgf Hi/+ embryos [44] [46].
Our results show that the shrimp hatchability test together with the lethality test could be an easy bioassay to screen marine natural products.
In this regard it is tempting to speculate about the possibility that some of the phenotypes associated with the absence of H2A.Z in metazoan cells, in particular lethality [42], [43], could be influenced by the corresponding SWR1-like complexes.
A comparable rescue of size was also observed in DdcGAL4 rescued animals, in agreement with previous observations where lethality of itprsv35/ug3 could be rescued by UASitpr+ expression in aminergic cells [4].
This was not the case in this study as lethality could not be demonstrated for most of these organisms at similar dosages and therefore could not be correlated with this condition.
