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As a a general example for synthetic lethality between two functionally distant genes, cell death might be the result of a disruption of a gene involved in DNA repair and another one with an important function in the primary metabolism.
While physical interaction or synthetic lethality between two TFs does not necessarily imply that they act together as cofactors or even target the same genes, we nevertheless find that these types of evidence are associated with significant signals of affinity co-conservation.
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Tetrad analysis of double heterozygous mutants of gpn2 -2 NPA3 ::DAmP (decreased abundance by mRNA perturbation; Breslow et al. 2008) showed synthetic lethality between these two genes.
Comparing the results of each gene targeted by RNAi in the wild-type and the JJ1549 strain, differences in percentage of embryonic lethality between the two strains were statistically analyzed.
Synthetic lethality describes the relationship between two genes or pathways, where loss of function of one gene or pathway in a cell is compatible with cellular viability, whereas loss of both is not.
Synthetic lethality describes a genetic interaction between two independently viable mutations whose combination results in lethality.
Synthetic lethality refers to a genetic interaction between two genes that cause cell death when they mutate concurrently, but neither by itself is lethal.
Synthetic lethality (SL) refers to the genetic interaction between two or more genes where only their co-alteration (e.g. by mutations, amplifications or deletions) results in cell death.
A synthetic-lethality genetic interaction (GI) network is defined by representing genes/proteins as nodes, with an edge between two nodes if a synthetic-lethality interaction has been observed between the corresponding genes.
Similarly to BE × BE, crosses between two BE2 individuals yielded embryonic lethality in approximately one fourth of the progeny (22.9% of 1488 progeny in eight families) and enlarged eyespots in two thirds of the adults (64.8% of 429 adult offspring).
Synthetic Lethality refers to a specific type of genetic interaction between two genes, where mutation of one gene is viable but mutation of both leads to death [10].
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