Sentence examples for lethality between the from inspiring English sources

Nevertheless, cancer cells can be killed indirectly through synthetic lethality between the cancer drivers and their synthetic lethal partners, as has been demonstrated using the PARP inhibitor olaparib to eliminate breast cancer early onset (BRCA -mutant ovarian and BRCA -mutantr cells [ 165, 171, 172].

Synthetic lethality between the nuclear function of PAB3 and Gle2p suggests the inner face of the NPC as a possible site of PAB3 action in the nucleus.

Comparing the differences of embryonic lethality between the wild-type and the mutated strain JJ1549 genotype efl-1 (se1), the value of each synthetic interaction was detected and calculated.

Comparing the results of each gene targeted by RNAi in the wild-type and the JJ1549 strain, differences in percentage of embryonic lethality between the two strains were statistically analyzed.

Regardless of the mechanism leading to the increased mutation rate ratio with decreasing lethality between the first division and gametogenesis, the trend is clear, and one can envisage that for neutral or nearly neutral mutations, the ratio may be even greater.

It has resulted in efficacy in mouse models of carcinogenesis that result from APC and KRAS mutations, and is being tested in breast cancer chemoprevention, based on the synthetic lethality between the mutated tumour suppressor genes BRCA1 or BRCA 2, and PARP1 (Fong et al, 2009).

The proven synthetic lethality between deficiencies in the HR-dependent DNA repair genes, BRCA1 or BRCA2, and PARP-1 inhibition has opened up several directions of clinical trials.

To confirm the synthetic lethality between adenylate cyclases and FH, the two highest ranking shRNAs identified by the primary screen, targeting the expression of ADCY3, ADCY6, ADCY7 or ADCY9, were individually sub-cloned into the library expression vector pRSI9 (shRNA sequences are shown in Additional file 4).

We also performed an extensive examination of literature to evaluate other evidence for the putative synthetic lethality relationships between the identified genes and p53.

We identified important regulatory networks and functional categories pertinent to these genes, and performed an extensive survey of literature to find experimental evidence that support the synthetic lethality relationships between the genes identified and p53.

To elucidate the molecular mechanism of the synergistic lethality between ABT-869 and SAHA, we compared the gene expression profiles of MV4-11 and MOLM-14 cells treated with DMSO control, ABT-869, SAHA and combination therapy using the Affymetrix microarray platform.