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The lethality attributed to hospital candiduria by C. famata was 42% (P<0.05), with identification of secondary infection in the blood stream in two patients.
Mutations in Col4a1 and Col4a2 orthologs in C. elegans have also been shown to cause intracellular accumulation of COL4A1 and COL4A2 and lead to temperature sensitive lethality attributed to contraction-induced detachment of the body wall muscles.
Identify the risk factors for hospital candiduria by C. famata, the lethality attributed to this infection, as well as evaluate the impact of early treatment with fluconazole on the lethality of candiduria.
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In the Zhao [ 17] RFC1 knockout mouse model, perinatal lethality was attributed to a marked absence of erythropoiesis in bone marrow, spleen, and liver.
Nearly 90% of tumor lethality can be attributed to metastases.
Although no inherited diseases are known to result from mutation of these genes, one case of neonatal lethality has been attributed to a defect in Drp1 (25).
The greater sensitivity of C4 cells to TMQ-associated lethality may be attributed to the greater extent of TMQ-mediated DNA damage and more prolonged duration of DHFR inhibition after drug exposure.
We showed that the male lethality cannot be attributed to the aromatic repeat sequence at the C-terminus, but rather must be located more upstream in a poorly characterised region of the protein.
Consistent with a role for BRD4 as a key mediator of ESCs identity, Brd4-null mouse embryos display postimplantation lethality that was attributed to degeneration of the inner cell mass (Houzelstein et al., 2002).
Lethality could not be attributed to differences in protein levels (Fig. 7).
Although the mechanism responsible for this lethality has generally been attributed to a defect in cell cycle progression through G1, based on studies using a dominant-negative and inducible form of C-Myb [15], neither the molecular basis of embryonic lethality nor its function in ES cells has been evaluated.
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