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The double mutants were maintained only as heterozygous for rnt-1 because of the lethality attributable to protruded intestine through the vulva phenotype.
DOI: http://dx.doi.org/10.7554/eLife.09178.004 > -wrap-foot> The variation in embryonic lethality attributable to informational modifiers, represented by genetic strain effect in our statistical model, provides an estimate of each strain's sensitivity to exogenous germline RNAi.
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We now show that the Byg strain harbors a disrupted Gga2 allele that is hypomorphic, indicating that the Byg lethality is attributable to a mechanism independent of GGA2.
Losey said there's been a decrease in the lethality of LRA activities attributable to U.S. and partner nation efforts.
This finding suggests that the conditional lethality of pro3 -1 is most likely attributable to the QC degradation of the misfolded polypeptide, leading to depletion of the essential protein at restrictive temperature.
These results confirm that the embryonic lethality of the Byg Gga2 −/− mice is not attributable to the absence of GGA2.
Mutation of Spen in mice causes embryonic lethality (Kuroda et al., 2003), which might be partly attributable to a repressive function in the Notch signaling pathway (Yabe et al., 2007).
Our results, of a low proportion of lethality in young genes, contrasts with a previous conclusion that young genes have a similar proportion of lethality as old genes [ 21], a result that might have been attributable to the off target effects of RNAi on duplicated genes, producing false positives for the essentiality of the young duplicated genes.
Recent growth is largely attributable to immigration.
That may be attributable to the economy.
Attributable to rotation of earth.
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