Sentence examples for lethality at a from inspiring English sources
Thus, this analysis uncovered unanticipated limitations regarding rad61 bypass of Ctf7 function but confirm rad61-bypass of ctf7 null cell lethality at a wide range of temperatures.
This dual regulation could not be dissected by removing the C-terminal dorain or YENPTY motif, since the full length APL-1 rescue of lethality at a lower expression level still could not rescue the aldicarb hypersensitivity.
C24 was less severe and results in lethality at a later pupal stage than N4, while FL26B was semi-viable and was therefore the weakest allele of the three (Figure 3A).
PU.1 mutants lead to embryonic lethality at a late gestational stage (Scott et al, 1994).
Similarly, mutation of other genes ensuring genome integrity, such as the catalytic subunit of pol ζ (Rev3), are viable in yeast but cause embryonic lethality at a similar stage in mutant mice (Esposito et al., 2000; Wittschieben et al., 2000).
The Sin3 multiprotein complex plays a central role in gene silencing by deacetylating histones, and deletion of the mouse SIN3A gene results in lethality at a postimplantation stage of development [ 1].
Polδ absence caused lethality at an earlier embryonic stage than these aforementioned DNA polymerases.
In C. elegans vinculin deficiency leads to the loss of muscular activity and lethality at an early larval stage (Barstead and Waterston, 1989).
In the mouse, targeted disruption of the S1P-encoding gene Mbtps1 prevented normal epiblast formation and subsequent implantation of the embryo (Mitchell et al. 2001), resulting in lethality at an early developmental stage (Yang et al. 2001).
Interestingly, knockout of genes encoding mTOR or the complex 1 component raptor causes a cell proliferation defect and early embryonic lethality at E6.5, a phenotype closely resembles that in Pik3c3 knockout mice [43], [44], [45].
Can a mosquito strain with the necessary properties – repressible dominant lethality acting at a larval or pupal stage – actually be constructed?
