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Synthetic interactions (such as synthetic lethality) are a hallmark behavior of genes involved in a common function [40].
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Synthetic lethality is a lethal phenotype caused by the combined effects of mutations in two or more genes.
Synthetic lethality is a term to describe the combined lethal effect of two genetic variations that are otherwise non-lethal when occurring in isolation.
"Severity of infection, including lethality, is a complex biologic phenomenon involving pre-existing immunity to pathogens, individual susceptibility, pathogen dose, etc.," said Kawaoka in an e-mail reply to Science.
Here an attempt has been made to study the characteristic features such as physical dimensions, mechanism of action of this weapon and to compare its penetrating ability with that of air gun, whose potential lethality is a well-documented fact, using the ballistic gelatine blocks at various ranges.
In this model system, lethality is a rather clear-cut parameter and, based on the number of mice killed, strains are classified as non-killer (<2 of 10 mice killed), killer (>8 mice killed) [49] or intermediate.
Our finding that ctf7 ctf18 double mutant cell lethality can be bypassed by additional deletion of RAD61 indicates that ctf7 ctf18 lethality is a result of cohesion defects and not severe DNA replication defects since rad61 deletion specifically reduces ctf7 mutant cohesion defects [36].
Lethality is a crucial factor to characterize the biological essentiality of a protein.
Furthermore, embryonic lethality was a main drawback of the conventional GEM models.
Synthetic lethality is a broader concept and in general covers any combination of genetic events that induces lethality in cells.
Alert readers will have realized that larval lethality is a pretty difficult phenotype with which to work.
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