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However, they had limitations, such as embryonic lethality and less than 100% accuracy in mimicking the human tumor spectrum.
Similar(59)
The Paak-2::aak-2 gfp aak-2 gfprescued transgenelity and, albeit less effectively, the ectopic gerescuedproliferathen phenotype observed in ampk mutants during lethalityse (Fig. 3and).
Barbiturates were frequently used historically as sedatives, induction agents, and for conscious sedation, then became less popular with the advent of agents with shorter duration of action and less lethality in overdose [5, 6].
In contrast, beta-emitting radionuclides result in fewer than 20 ion pairs per micrometre and commonly cause only single-strand DNA breaks with less lethality and more spillover effects caused by "crossfire" (Fig. 1).
In the study by Schouten and colleagues, PAR1 impairs the host defence response, as reflected by a reduced lethality, lower bacterial loads, less pulmonary neutrophil influx and less lung damage in PAR1 knockout mice [ 1].
We show that in pneumococcal pneumonia, PAR-1 impairs host defense, as reflected by a reduced lethality and lower bacterial loads, lung histopathology scores and less pulmonary neutrophil influx in PAR-1 KO mice.
We show that in pneumococcal pneumonia, PAR-1 impairs the host defense response, as reflected by a reduced lethality, lower bacterial loads, lower lung histopathology scores and less pulmonary neutrophil influx in PAR-1 KO mice.
Thus complete sequestration of the MBNL1 and MBNL2 proteins in CUG foci may lead to embryonic lethality with less complete sequestration in various cell types and organ systems leading to viable but impaired individuals exhibiting a variety of pathological features (Charizanis et al., 2012; Lee et al., 2013).
LPCAT3-deficient mice display similar lethality and enterocyte lipid accumulation, and have less TGs in plasma lipoproteins.
100 μL PBS was used as a negative control and snake venoms that are known to induce lethality in less than 5 h at these concentrations were used as positive controls [ 30].
SSRIs and SNRIs are generally better tolerated and safer than TCAs and MAOIs, having less anticholinergic effects, toxicity, lethality, and psychomotor or cognitive impairment [ 85, 101].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com