This RBP belongs to the ELAV (Embryonic Lethal Abnormal Vision) family of proteins [13].
Nestin MO did not influence Elavl3/4 (Embryonic lethal, abnormal vision, Drosophila-like 3/4) (a neuronal marker), or otx2 (a midbrain neuronal marker), but severely perturbed cranial motor nerve development and axon distribution.
A current model proposes that a balance between the antagonistic activities of MBNL1 and polypyrimidine tract binding protein (PTB), which promote exclusion of exon 5, and CUG binding protein 1 (CUG-BP1) and embryonic lethal abnormal vision type RNA binding protein 3 (ETR-3), which promote exon 5 inclusion, instructs the spliceosome to retain or not exon 5 in mature transcripts [10].
HuR belongs to the ELAV (embryonic lethal abnormal vision) family found in mammalian cells containing four members: HuR, HuB, HuC, and HuD.
(ER-): Estrogen receptor negative; (ER+): estrogen receptor positive; (RIP): RNA immunoprecipitation; (RIP-Chip): RNA immunoprecipitation applied to microarrays; (3' UTR): 3' untranslated region; ELAV1: (embryonic lethal abnormal vision 1).
HuR is the ubiquitously expressed member of the embryonic lethal abnormal vision (ELAV /Hu protein family, which also comprises the primarily neuronal proteins HuB, HuC, and HuD [ 12].
Additionally, we ectopically expressed Abd-B.m by using an embryonic lethal abnormal vision (elav) driver line, which directs expression in all neuronal tissues from St12l on, but is not expressed in the NE.
Two further genes, which have not been explicitly studied in the context of oogenesis (references in Additional file 1), were investigated: embryonic lethal abnormal vision (elav) and minibrain (mnb).
On the basis of partial cds sequence (GI: 93115149) of O. mossambicus ELAVL1 (embryonic lethal, abnormal vision, Drosophila-like 1), we identified the SNP polymorphism A/G (Table 1) at nucleotide 391 in our mapping family.
