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Introduction Severe Acute Pancreatitis (SAP) is a common but potentially lethal pathology due to the multiplicity and severity of complications that can occur at all stages of evolution.
For 12.2%, no lethal pathology was identified and CKS was considered as the underlying cause.
Of the 946 deaths, 65.9% were attributable to non-neoplastic conditions, 21.9% to malignancies, and 12.2% to KS (that is, deaths for which no lethal pathology was identified).
For 116 (12.2%) death certificates, there was no mention of any lethal pathology; thus KS was considered as the cause of death ('KS alone').
In these cases, the lethal pathology was considered as the underlying cause (as mentioned, CKS is rarely considered an actual cause of death); if more than one lethal pathology was written, we selected the most plausible cause based on an internationally accepted hierarchy of causes of death in ICD-9, which is used by ISTAT.
This suggests that the levels of IL-10 were protecting the majority of the infected Clecsf8−/− mice from lethal pathology, despite the enhanced inflammation and bacterial burdens that were present in their lungs.
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Of these, 275 (56.6%) had both KS and one or more lethal pathologies written as the underlying cause (for example, malignant tumours, circulatory system diseases, and respiratory system diseases).
The latter data indicated that a lack of Treg or Treg-functional capacity was responsible for the lymphoproliferation and lethal autoimmune pathology in mutant mice.
Damaged cells thereby exert comprehensive impacts to surrounding tissues with the accompanying, inherent, and conserved phenotype-DDSP, which can be turned on after clinical administration of genotoxic therapies against the extremely lethal human pathology, cancer (Fig. 2).
While in most situations, namely viral infections, this class of cytokines is indispensable for host survival they mediate a detrimental effect during infection with L. monocytogenes by rendering macrophages insensitive towards IFNγ signalling which leads to a lethal bacterial pathology in mice.
Contrary to the lethal human pathology, the mdx mouse somehow recovers from the progressive muscle wasting, and does not show the accumulation of connective and adipose tissue[ 17, 20].
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