Sentence examples for lethal interaction from inspiring English sources

A synthetic lethal interaction implies a functional relationship between the interacting genes.

(e) Synthetic lethal interaction between Myc and knockdown of RHOA.

Corcoran, R.B. et al. Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models.

Bcl-2 is a biomarker for the synthetic lethal interaction of IDF-11774 with ATP6V0C, which is clinically applicable for the treatment of cancer patients with IDF-11774 or autophagy-inducing anti-cancer drugs.

Immunostaining with active caspase-3 antibody revealed a widespread Myc-dependent apoptosis in the RHOA-deficient structures (Figures 3e and f), thus exposing a strong synthetic lethal interaction between loss of RHOA and Myc activation.

In these cells, TBK1 activated NF-kappaB anti-apoptotic signals involving c-Rel and BCL-XL (also known as BCL2L1) that were essential for survival, providing mechanistic insights into this synthetic lethal interaction.

This time lawmakers tried to help folks whose financial lives were shattered by the lethal interaction of the 2000 tech-stock crash, incentive stock options and the alternative minimum tax.

Synthetic lethal interaction is an extreme of the negative interactions.

First, the current synthetic lethal interaction network is heavily biased.

Synthetic lethal interaction analysis, in which the deletion of two viable genes makes the organism (yeast) inviable, generated the first large-scale synthetic lethal interaction data set [5].

In the context of synthetic lethal interaction data alone, the global similarity of synthetic lethal interaction patterns between two genes is used to predict gene function.