We obtained the protein lethality information from MIPS database [ 17], which reports whether a protein is lethal or viable.
The nduf-7 (et19 ) is likely a partial loss-of-function allele because the more severe nduf-7 (tm1436 ) allele, which lacks the second exon and part of the third exon, is lethal (Supporting Information, Figure S1).
To explore whether genes putatively under recent positive selection in our data set (i.e., affected by a hard sweep during recent human evolution) have important fitness effects, we classified the genes under study as viable or lethal using information from The Mouse Genome Database (Bult et al. 2008).
If all alleles but one are lethal then the information content is maximal, as the non-lethal allele will always be found at that locus.
Except for some rare or lethal conditions, genetic information may become so commonplace with NGS that, in the absence of rare or lethal conditions (eg Huntington's disease), such information could be treated in the same way as other medical and lifestyle information.
The Ministry of Defence knew that rubber bullets used during the Troubles caused serious injuries and could be lethal but concealed the information from victims, according to documents uncovered in the National Archives.
An Associated Press survey of the 32 states that practice capital punishment found that the vast majority have passed laws shielding information about lethal injection drugs and their suppliers.
An online veterinary manual provides information on lethal doses of ethylene glycol for chicken, cattle, as well as cats and dogs, adding that younger animals may be more susceptible.
However, because of the potential for harm noted in at least 1 study of a rare but highly lethal cancer (9), additional information concerning the association of vitamin D with rarer cancers is needed.
The W.H.O. and public-health agencies like the Centers for Disease Control and Prevention find themselves in a delicate balance, obliged to provide information about potentially lethal diseases without causing panic.
