As shown in Fig. 9A, U18666A protected cells from anthrax lethal toxin induced cleavage of MEK1.
The pioneering anatomical screen of Nusslein-Vollhard and Wieschaus examined cuticle patterns of unhatched embryos bearing lethal mutations induced by the chemical mutagen ethyl methanesulfonate (EMS) [1].
In a nutshell, we report the identification of an efficient siRNA that can potently protect mice against lethal encephalitis induced by CHPV and utility of the cationic lipids for effective brain delivery.
Additionally, catalase activity significantly correlated to robustness towards multiple lethal stresses induced upon pretreatment to mild acid or mild oxidative stress, and functioned therefore also as divergent-application biomarker.
Here we exploit the lethal phenotype induced by intra-abdominal injection of CrPV into adult Drosophila to characterize a genetically tractable in vivo host-virus model system and identify genes involved in innate antiviral responses.
IRF-5 knockout mice showed resistance to lethal shock induced by either unmethylated DNA or lipopolysaccharide, which correlates with a marked decrease in the serum levels of proinflammatory cytokines, and thus identifies IRF-5 as a key player in the TLR-Myd88 signaling pathway [5].
Ectopic expression of male-specific lethal 2 (msl2) induces dosage compensation in females (Kelley et al. 1995).
Several molecules have been isolated and tested against some lethal activities induced by snake venoms [ 9– 11].
Deletion of Dkc1 has been shown to be embryonically lethal if induced during early embryogenesis [55].
Genetic defects in WSX-1 make animals more susceptible to lethal inflammation induced by parasitic infection [ 31].
Lethal influenza induces procoagulant and antifibrinolytic changes in the lung which can be partially prevented by rm-APC treatment.
