Sentence examples for lethal impairment from inspiring English sources

Using the genome comparison software Genlight, two separate in silico workflows were implemented to derive a set of parasite proteins for which gene disruption of the orthologs in both the model organisms yielded deleterious phenotypes (e.g., lethal, impairment of motility), i.e., are essential genes/proteins.

The compression of morbidity hypothesis proposed by James Fries in 1980 [ 23] postulates that as the limit of human lifespan is approached, the onset and duration of lethal impairment compresses toward the end of life.

Similarly, genetic combinations that yield a non-lethal growth impairment are called synthetic sick but are usually grouped together with synthetic lethal interactions, as is done in this review.

Given that organ dysfunction/injury in DIED mice was more pronounced at many but not all time points compared to SUR, we next aimed to characterize the dynamics of progressive pre-lethal organ impairment in acute CLP.

Other possible factors include sub-lethal toxicity and impairment of soybean root physiology following accumulation of residual glyphosate and/or AMPA in root tissues [99, 100], and herbicide-induced disruption to rhizosphere-dwelling organisms associated with nutrient acquisition (see "Pathway I: disruptions to rhizosphere microbial ecology" section).

First, the resource availability increases due to lethal and sublethal impairments of the more sensitive species (Culex in this study).

The global birth prevalence of congenital disorders that are lethal or cause lifelong impairment is estimated to be 5%to7%7% [ 2, 3].

NL1 3 triple KO mice are neonatal lethal, and massive synaptic impairments have been observed from both in vitro and in situ analysis of these mice.

Among them, SRS2, SGS1 and RRM3 genes show overlapping roles in genome maintenance as demonstrated by growth impairments or lethal phenotypes when mutations in these genes are combined [22,37 41].

As member of a ubiquitin-mediated proteolysis complex, the function of KEAP1 is probably essential to the cell, and its impairment is likely lethal.

Gene knockouts might also contribute to a lethal embryo phenotype through direct impairment of placental function or development and, for this reason, any comprehensive screen to analyse recessive lethals should also include systematic assessment of placental structure (Adams et al., 2013).