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The lethal factor of Bacillus anthracis is a major factor for lethality of anthrax infection by this bacterium.
Dr. Liddington said drugs against lethal factor might be ready to test in 18 months.
Lethal factor, the other anthrax toxin, also inhibits cytokine production, though through a different mechanism.
Dr. Liddington worked out the structure of lethal factor last year.
Moayeri, M. et al. Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection.
By working out the exact anatomy of lethal factor, Dr. Liddington has provided the information required by drug designers to synthesize small chemicals that would interact with lethal factor and block its function.
Dr. Liddington's team has worked out the exact structure of lethal factor, a principal component of anthrax's three-part toxin.
The protective antigen then collects lethal factor or edema factor from the bloodstream and injects them into the target cell.
Protective antigen (PA) and lethal factor (LF) are the two components of anthrax lethal toxin.
Levinsohn, J. L. et al. Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome.
Hellmich, K. A. et al. Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages.
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