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Major depression is a potentially lethal disorder, with mortality rates of around 15 in 100 -- mainly due to suicide.
Subacute necrotizing encephalopathy, also called Leigh disease, is a lethal disorder of infancy marked by psychomotor delay, myoclonic jerks, paralyses of eye movements, and respiratory disorders.
Complicated type B aortic dissection is a lethal disorder, which requires immediate endovascular or surgical treatment.
Complicated acute type B aortic dissection is a lethal disorder that requires emergency treatment [1, 2].
Giant cell myocarditis (GCM) is a rare and highly lethal disorder.
MCAD deficiency is a potentially lethal disorder of fatty-acid oxidation.
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Dominating the therapeutic frontier for these potentially lethal disorders, cell and gene therapies aim to relieve or eliminate patient suffering by restoring the function of damaged, diseased, and aging cells and tissues via the introduction of healthy cells or alternative genes.
Though the purebred Arabian produces a limited range of potential colors, they do not appear to carry any color-based lethal disorders such as the frame overo gene ("O") that can produce lethal white syndrome (LWS).
Clinical manifestations of mtDNA deletion syndromes range from acute, multisystem, and often lethal disorders in infants and young children, to relatively mild neuromuscular symptoms that are often of adult onset [8].
An important and consistent finding in this study and others [1], [11] is that renal agenesis, renal hypoplasia, dysplastic and cystic dysplastic kidneys can co-occur in individuals with bilateral lethal disorders of kidney development.
Mendelian phenotypes in humans vary from benign variants to lethal disorders.
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