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One of the most important challenges in medical treatment is invention of a minimally invasive approach in order to induce lethal damages to cancer cells.
Recently, a novel and efficient mutation tool called atmospheric and room-temperature plasma (ARTP) has been successfully employed to cause some significant changes in enzyme activity, biochemical productivity, and metabolism without lethal damages (Guo et al. 2011; Lu et al. 2011; Xu et al. 2012; Wang et al. 2014).
Of these, DSBs are believed to be one of the most lethal damages induced by DNA damaging agents (Collis et al, 2005).
The survival curves of sarcospheres clearly showed a shoulder at lower and, therefore, clinically relevant doses of irradiation, which is probably due to an enhanced capacity to repair potential lethal damages.
The famous phenomenon of the multiplicity reactivation in bacteriophage T4 [ 84] is a remarkable model example of such a recombination effect, when the viable phage particles are formed after infection of the bacterial cell with two or more phage particles each of which bearing several lethal damages.
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However, immediate plating following radiation allows expression of the so-called 'potentially lethal damage' and boosts radiation-induced lethality by a large factor (Little et al, 1973).
For this reason, PARP inhibitors were first developed as radio- or chemo-potentiating agents [ 20, 21], the aim being to overcome cancer cell resistance to a DNA-damaging agent by preventing repair of the potentially lethal damage to the cancer cell caused by the treatment.
He said: "It had the potential to cause lethal damage.
Divisions in our continent – a continent of which, as the Queen said, Britain is part – have done lethal damage.
The victims were essentially flash-frozen, bypassing the lethal damage that the body suffers during a slower descent into hypothermia.
"How a Torn Aorta Can Do Lethal Damage" (Dec. 21) mentions that aortic tear may be unfamiliar to most people.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com