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Plus, the GS4 touts 2GB of RAM, which becomes lethal combined with the Snapdragon 600.
While the mutation of any two individual genes is not lethal, combined mutations in both genes causes cell death.
Indeed, genes expressed in 31-39 tissues were most likely to be lethal at P14 [ P<0.0001, Fisher's exact test comparing the ratio of viable and abnormal viability (subviable and lethal combined) gene sets between the groups with 0-3 and 31-39 positive structures].
Genes causing lethality when inactivated were more likely to be expressed in a large number of tissues [ Fig. 5 and Table S3; P<0.0001, Fisher's exact test comparing the ratio of viable and abnormal viability (subviable and lethal combined) gene sets between the groups with 0-3 and 31-39 positive structures].
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Synthetic lethality occurs when two lesions that are individually non-lethal become lethal when combined.
Synthetic lethal mutations (non-lethal when alone but lethal when combined in one genome) have been studied to develop cancer therapies.
Co-lethality, or synthetic lethality is the documented genetic situation where two, separately non-lethal mutations, become lethal when combined in one genome.
Many of these alleles are lethal in the homozygous state, lethal when combined, or sublethal due to anemia.
In contrast, transgenic expression of the yeast alternative NADH dehydrogenase Ndi1 was synthetically semi-lethal with tko 25t and was lethal when combined with both AOX and tko 25t.
He wrote [ 2] in his 1945 paper: "Chromosomes A and B evidently contain genes, or groups of genes, which taken separately are not lethal to homozygotes raised at 16.5 degrees, but which become lethal when combined by crossing over.
One remarkable result of these synthetic lethal interactions is that neither the SA nor the SE mutation is lethal when combined with dyn1Δ or kar9Δ deletions (Table 2).
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