Duchenne muscular dystrophy (DMD) is a progressive neuromuscular disorder, ultimately lethal, caused by the absence of dystrophin protein due to mutations of the dystrophin gene.
More recently, M. circinelloides is attracting special attention as a causal agent of mucormycosis, an emerging fungal infection, not very common but often lethal, caused by various species of the order Mucorales [ 7].
In fact, of all the natural disasters that can strike extreme temperatures are the most lethal, causing more deaths overall than floods, earthquakes and tornadoes.
We show that postnatal deletion of mouse Ate1 (its unconditional deletion is embryonic lethal) causes a rapid decrease of body weight and results in early death of ∼15% of Ate1-deficient mice.
In contrast to chlorpyrifos or diazinon, parathion was much more lethal, causing significant mortality at doses > 0.1 mg/kg.
Paralogs or redundant genes are called SSL gene pairs if the combination of two mutants, neither by itself lethal, causes the organism to die or malfunction.
Cited2 deletion in mice is embryonic lethal, causing multiple developmental defects (Bamforth et al., 2001; Yin et al., 2002), including impaired fetal liver hematopoiesis (Chen et al., 2007).
If the outcome was lethal, causes of death were other diseases (9.2%), secondary tumor (7.4%), local recurrence (3.5%), nodal recurrence (0.5%), and distant metastasis (0.2%) [ 25].
Until recently, four distinct species were recognized as human pathogens: P. falciparum, P. vivax, P. malariae, and P. ovale, with P. falciparum the most lethal, causing the majority of deaths.
Additionally, we discovered natural auto-control mechanisms, such as the sex-linked lethals causing distorted sexual ratios.
Synthetic lethality is a lethal phenotype caused by the combined effects of mutations in two or more genes.
