Sentence examples for lethal aberration from inspiring English sources

When we determined the relationship between survival and radiation-induced chromosome aberration frequency, a measure independent of most other modifiers of sensitivity, we observed a direct relationship between ploidy and mean lethal aberration frequency.

All LRRK HA lines that we generated were viable, suggesting that the procedure did not induce second-site lethal aberrations.

It is established that the creation of a DNA double-strand break (DSB) represents the principal lesion that, if not adequately repaired, can lead to cell death via the generation of lethal chromosomal aberrations or the direct induction of apoptosis.

The mean lethal frequency of aberrations was independent of DNA repair variations.

The mean lethal frequency of aberrations increased from about 1 for diploid cells to about 2 for tetraploid cells.

Strategies for in vivo germ cell testing include the mammalian spermatogonial, chromosome aberration, dominant lethal (Russell and Russell 1954; Ehling 1974), specific locus (Ehling et al. 1978; Russell et al. 1981) and mouse heritable translocation assays (see Eastmond et al. 2009).

For example, GO category Immune response was enriched in 0% and depleted in 97% of the less lethal tumours, whereas the aberration frequencies in other tumours were 54% and 9% for enrichment and depletion, respectively.

Most of the CA observed in cells are lethal, but there are many aberrations that are viable and can cause genetic effects, either somatic or inherited [ 56].

The hopes for generating selective cancer drugs by virtue of their synthetic lethal interactions with tumour-specific aberrations are only beginning to materialise.

The availability of large-scale synthetic low-molecular-weight chemical libraries has allowed HTS for compounds synergistic lethal with defined human cancer aberrations in activated oncogenes or tumour suppressor genes.

This assumption is also consistent with the possibility that subclones' viability may be hindered by the lethal synergy of some of their aberrations.