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He comes up with a tale, often said to be modelled on the story of the castaway Alexander Selkirk, that, like Bunyan's, follows an almost biblical pattern of transgression (youthful rebellion), retribution (successive shipwrecks), repentance (the painful lessons of isolation) and finally redemption (Crusoe's return home).
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His essay about his encounter with a mysterious man who teaches him lessons about escaping his own sense of isolation is haunting and very moving.
Not only are these all individually great techniques, the synergy between them makes the system considerably more secure than it would be if we only applied one or two of the lessons in isolation.
There are lessons to draw here, among them what I've noted already: that one consequence of isolation is seeing standard metrics of success as not just unattainable but as the property of people not like us.
However, as I emerged from the numbing sense of isolation I realised that my mother's life had taught me three valuable lessons I would probably never have learned without her untimely death.
Here scientists have fewer hard answers, but we can at least look to the lessons of individuals who thrived – or floundered – under isolation.
The effects of isolation?
The tragedy of isolation?
A sense of isolation prevails.
The effect of isolation was dramatic.
Albania's cocoon of isolation was shed.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com