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Maximakinin is an agonist of the human and rabbit B2R with a 8 12 fold lesser potency, but a prolonged duration of action relative to BK (ERK MAP kinase activation, c-Fos induction in HEK 293 cells).
Thus, differences in gene regulation between C22 6 and WY14643 could not entirely be accounted for by the lesser potency of C22 6.
(pointing to contraceptive pills) Ayesha: It may be of lesser potency.
On the other hand, FDA may also bind at lower affinity to other uterotonin receptors, which may explain lesser potency of FDA as uterotonin as compared to oxytocin, PGF2α and Ach.
Patients were evaluated for use of low-dose corticosteroids (equivalent or lesser potency to hydrocortisone 50 mg/6 hourly plus 50 μg 9-alpha-fludrocortisone) for the treatment of severe sepsis and vasopressors (>5 μg/kg/minute of dopamine; any dose of epinephrine, norepinephrine, phenylephrine, vasopressin or milrinone) at any time in the ICU.
Patients enrolled in the PROGRESS registry were evaluated for use of vasopressor and LDC (equivalent or lesser potency to hydrocortisone 50 mg six-hourly plus 50 μg 9-alpha-fludrocortisone) for treatment of severe sepsis at any time in intensive care units (ICUs).
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Such low concentrations and lesser potencies of 4-hydroxyalprazolam and α-hydroxyalprazolam suggest that they are unlikely to contribute much to the pharmacological effects of alprazolam.
Though in vitro plants show slightly lesser antimicrobial potency as compared to ex vitro plants, they can be produced in large quantities using very little space throughout the year.
These compounds may have been introduced as substitutes for the better-known antiandrogenic phthalates (DBP, BBP, DEHP), even though they are also EDCs and have similar (DCP) or lesser (DINP, DPP) potency (Boberg et al. 2011; Hannas et al. 2011; Heindel et al. 1989; Saillenfait et al. 2009).
Changes take place in its contents with exposure to air and loss of the antioxidant radicals and citric acid occurs from the concoction making its potency lesser the more it is exposed to the environment.
Inhibitors of α-amylase and α-glucosidase isolated from medicinal plants to serve as an alternative drug with increased potency and lesser adverse effects than existing synthetic drugs.
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