Our results showed a trend toward lower angiographic restenosis and a lesser in-stent plaque burden at follow-up in the slotted tube stent compared with the self-expanding stent.
Confocal microscopy using antibodies to Aβ peptide, tau and peroxiredoxin 6 showed that peroxiredoxin 6 positive astrocytes are closely involved with diffuse plaques and to a lesser extent with neuritic plaques, suggesting that plaques are producing reactive oxygen species.
ARTE10 mice developed cerebral β-amyloidosis with similar morphology and composition as in human AD-affected brain, including mainly dense-core, and to a lesser extent diffuse plaques as well as amyloid angiopathy.
Neurons containing tau were not surrounded by activated astrocytes as were the diffuse plaques and to a lesser extent the neuritic plaques, suggesting that these cells are not secreting toxic or activating products that are stimulating to astrocytes.
Strongly staining peroxiredoxin 6 astrocytes appear to be involved in the detoxification of diffuse plaques and to a lesser extent in neuritic plaques, but is not associated with tau aggregations within neurons.
It should be noted, however, that in addition to mature (dense, cored) neuritic plaques, and to a much lesser degree diffuse Aβ plaques, [F]flutemetamol is retained by vascular amyloid deposits [ 22].
The variation in the cortical pattern appeared e.g. in occipital cortex, where layers 4 and 6 were virtually devoid of plaques and layer 5 displayed only a lesser number of diffuse plaques.
Note for calcified plaques the lesser extent of blooming when using a sharp-tissue (B46f) compared to a soft-tissue kernel (B26f).
There is accumulating evidence that individuals with high-normal or just greater than normal plasma bilirubin levels have a lesser incidence of CAD and carotid plaque formation (7, 8).
However, it has been widely reported that Alzheimer-type pathology (most often amyloid plaques, but also to lesser extent neurofibrillary tangles) often coexists with Lewy body pathology.
