I do think that the cover plays a lesser, non-essential role on an e-book, and I take this fact as further evidence that the physical book will survive.
Further functional studies have demonstrated that Shh (and Ihh to a lesser extend) play an essential role in the dorso-ventral and antero-posterior patterning of the neural tube [16], as well as in the definition of anterior-posterior polarity of the limbs.
Studies in Saccharomyces cerevisiae have shown that a P4-ATPase Drs2, which flips PS and to a lesser extent PE, is essential for membrane traffic between the late Golgi compartment and endosomes (Sebastian et al, 2012) and that other P4-ATPases Dnf1 and Dnf2, which flip phospholipids such as PC and PE, participate in endocytic vesicle formation (Pomorski et al, 2003).
We observed that phenodiv genes had significantly lesser clustering coefficient than the essential genes (Mann-Whitney P = 0.018; Mean ± S.D. = 0.12 ± 0.19 and 0.17 ± 0.24 respectively).
With the advent of minimally invasive TLIF techniques to achieve spinal fusion, it become essential to have lesser soft tissue dissection, low implant load without compromising the spinal stiffness, and reduction of surgical time, postoperative pain and hospitalization.
We indeed demonstrated that at all stages of symbiosis, genome reduction was specifically targeted to genes of lesser selective importance, or less essential for the survival of the host/symbiont couple.
Clearly, parameters involved in the negative loop can vary to a lesser extent if this loop is essential than when it is not essential.
On top of the work from Passing/Posing, the exhibition will feature the South Central born artist's lesser-known work, which is essential to understanding the full scope of his oeuvre.
In weighting architecture's aspects as essential, core, or some lesser status, a related question is whether one or another aspect is primary or necessary to any of the others.
Pandemics of lesser severity place fewer requirements on essential services.
