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Deferiprone treatment (15 mg/kg, twice daily) resulted in an improvement in clinical signs (e.g., gait, dysarthria, dystonia) and lessening of brain iron in two patients with NBIA of undetermined cause (Forni et al., 2008; Kwiatkowski et al., 2012).
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Another study showed improvement in executive function and overall emotional adjustment as well as lessening of depression and anxiety among brain-injured persons treated with NMT.
There must be no going back or lessening of momentum.
Ibuprofen showed lessening of effectiveness with time.
Lessening of inhibition, saying inappropriate things in inappropriate places.
"More work needs to be done to help identify the risk factors for those people, and then how we can help them, to lessen the burden of brain injury,".
Lifetime intellectual enrichment (estimated with education or vocabulary knowledge) lessens the negative impact of brain disease on cognition, such that people with greater enrichment are able to withstand more severe neuropathology before suffering cognitive impairment or dementia.
In fact, educational attainment actually reduces the negative effect of neurotic plaques (Bennett et al., 2003) and fibrillar β-amyloid (Roe et al., 2008) on cognition, and vocabulary knowledge lessens the negative effect of brain atrophy on cognitive efficiency in multiple sclerosis patients (Sumowski et al., 2009 b ).
The presence of medical tourism hospitals in developing nations is also thought to lessen the international brain drain of health human resources by providing surgeons and others with access to advanced, high technology work environments [ 3].
(In people, the problem of brain asymmetry is lessened by the significant overlap in the two visual fields).
However, deferiprone, which does cross the BBB, did lessen brain iron but did not improve clinical symptoms in a study of nine patients with PKAN (12.5 mg of deferiprone/kg, twice daily for 6 months) (Zorzi et al., 2011).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com