The report said there was a lack of younger people at entry-level positions, particularly as scientists and engineers, who would become future leaders and managers, as well as insufficient training to fill the gaps in skill caused by the reduction of employees and a lessened capacity to handle the higher rates of flight for a sustained period.
A number of these molecules offer molecular volumes 50 60% that of PTX, fewer contacts with the tubulin protein, severe mismatches with the PTX pharmacophore, lessened capacity to dispel binding site waters contributing to Δ Gbind, and unanticipated binding poses.
They predicted that silt would collect in its reservoir, threatening the stability of the dam and lessening its capacity to produce power.
"However, in the 1930s, declining output and falling prices (which increased real debt burdens) led to widespread financial distress among borrowers, lessening their capacity to pledge collateral…Borrowers' cash flows and liquidity were also impaired, which likewise increased the risks to lenders".
Impurities should be removed as they lessen its capacity.
To be sure, Burleigh concedes that Pius's "punctilious adherence" to "outward neutrality" eventually "would lessen his capacity to play a prophetic role in the war," though he goes on to quote approvingly Pius's own justification for silence, in December 1942: "The Pope cannot speak.
Our findings highlight the notion that elderly patients with CKD may be more susceptible to volume overload because the reduced intracellular volume caused by aging and malnutrition lessens the capacity of cells to retain fluid.
The latter result illustrates the role of runoff in shaping the flow paths it follows and, consequently, in lessening the surface storage capacity.
And while many show-runners initially vowed not to cross the picket line, some will soon or have already returned to work in a non-writing capacity, thereby lessening the guild's leverage at the bargaining table.
Again, note in passing how, in a realm of egalitarian team synergy, as in that of human intelligence, "inequalities" in merit often derive from "differences" in talents, leanings, and abilities, such multidimensional differences in personality (see Wolf et al. 2007 on the evolution of animal personalities) often improving the whole team's synergistic capacity instead of lessening it.
The resulting bronchodilation leads to increased functional or inspiratory lung capacity (with lung deflation), lessening the dyspnoea and the limitations placed upon patients' ability to undertake everyday activities [ 11, 12, 61– 63].
