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The etifoxine treated group showed a delay in onset (Fig 2G), as well as a lessened severity at the peak of EAE.
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However, statins may have a more useful role during acute infections, with the aim of lessening severity.
Pharmacogenomics being in use to a limited degree, such multidisciplinary research can lead to evidence-based results, impacting optimal promotive/preventive/curative healthcare management by early changes in lifestyle, avoiding or lessening severity of diseases, and decreasing cost and risk of clinical trials by targeting persons capable of responding to a drug.
From 2000, Tracey and colleagues have been working on the mechanisms by which electric stimulation of vagus nerve suppresses activation of NF- κB and production of proinflammatory cytokines in α7 nicotinic acetylcholine receptor- (α7 nAChR-) expressing macrophages and lessens severity of sepsis in animal models [ 1, 2].
He also found that relaxation lowered cholesterol levels and lessened the severity of angina attacks.
As we stop sending particulates into the air, we remove a shield that has lessened the severity of observable global warming.
A modelled management scenario demonstrated how river level stabilisation and limited irrigation could have prevented, or greatly lessened the severity of the acidification.
Even when the injections were given after the onset of symptoms, they significantly lessened the severity of, and in some cases reversed, the mice's paralysis.
(Also, decreasing the 'latent' period could have prevented the subsequent deformity or lessened the severity).
Cyclone Nilofar so far has lessened in severity.
They lessened the severity of poverty for 15.2 million more people, including 7.1 million children.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com