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The effect on the absolute difference that can be detected is less when dealing with smaller medians, such as would typically apply for an endpoint such as PFS.
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The battlefield narrative method which worked so well in Stalingrad is less effective when dealing with the wider conflagration, where military events often matter less than the underlying forces of ideology, political geography, or industrial production.
Current rule extraction approaches can successfully deal with problems with discrete-valued inputs but are less efficient when dealing with problems with continuous-valued inputs.
Explicit time stepping renders many high-resolution computational schemes to become less efficient when dealing with non-uniform grids typical of many aeroacoustic applications.
The Vatican, by and large, has been less intrusive when dealing with issues of sexuality and the priesthood in other European countries than it has in the United States.
The conversations about compensation, he said, tend to be less emotional when dealing with economic loss rather than with the loss of a loved one or a catastrophic injury.
Under Mayor Michael R. Bloomberg, the city has not entirely ended what the mayor has described as "corporate welfare," but it has become more selective and less generous when dealing with large companies.
All of them, it seems, are ideologically incapable of calculating that if the PCTs are inefficient, some hospitals poorly managed and GPs take us for a ride then the centrally elected government should reform the PCTs, transfer the best managers of hospitals to the poor performers and negotiate with less naivety when dealing with the pay demands of GPs.
EPs may not have been specifically trained to care for emergency geriatric patients; hence, many EPs reported being less comfortable when dealing with older patients [29].
Traditional techniques such as the finite-differences method and lattice become less attractive when dealing with pricing derivatives with multiple stochastic variables, problems with many dimensions, or even path-dependent American options, as it is the case of American Asian (Amerasian) options.
When analyzing the two types of simulated data sets, it clearly appeared that both models were less powerful when dealing with completely isolated populations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com