Sentence examples for less well differentiated from inspiring English sources
It has been proposed alternatively that a proportion of these low-grade invasive tumours might de-differentiate over time into more aggressive, less well differentiated tumours (Tabár et al., 1999), although this was not found in another screening programme (Hakama et al., 1995).
The overall gene expression phenotype of Dicer-null NS cells is complex and cannot simply be defined as corresponding to a more or less well differentiated neural stem cell type: transcripts found in neurons and glia are at comparatively high levels in Dicer-null NS cells, along with many positive cell cycle regulators and genes that drive self-renewal or repress differentiation.
Resistant cells, designated ZR-75-9a1 ZR-75-9a1 ZR-75-9a1gical changes consistent with the acquisition of a less well displayediated phenotype.
6, 14– 19 When these FDG-avid tumors were correlated with histology, they tended to be less well differentiated and had more aggressive histological features.
Tumours tend to be larger, less well differentiated, more likely to be lymph-node positive and more likely to metastasise compared to tumours found in older women.
These tumors, termed 'luminal B', are hyper-proliferative and less well differentiated and benefit from chemotherapy in addition to anti-estrogens.
It has been proposed alternatively that a proportion of these low-grade invasive tumours might, if not detected, de-differentiate over time into more aggressive, less well-differentiated tumours.
Higher-grade endometrioid adenocarcinomas have less well-differentiated cells, have more solid sheets of tumor cells no longer organized into glands, and are associated with an atrophied endometrium.
Patients with well-differentiated tumours had a slightly reduced risk of death compared with patients having less well-differentiated tumours.
Polycomb target hypermethylation has previously been associated with the cancer phenotype and less well-differentiated tumours [ 52].
Notably, women with higher nodal status were more likely to be younger and had larger and less well-differentiated primary tumors.
