On the other hand, the immunopositivity is less informative since we cannot exclude the presence of Maspin- negative areas with a lesser degree of differentiation and with aggressive potential.
Sampling in other areas was less intensive, and we cannot exclude the possibility of unsampled epigean populations or species in Clades A and B. Overall, the Plateau Nesticella clade was composed exclusively of troglobites.
However, with clearly fewer men, and less variation in the dependent variable (due to less absence among men), we cannot exclude a similar effect on men using the current findings.
For this reason we considered them less noteworthy, even if we cannot exclude that their specific role in the process of adaptation may have been relevant.
These data suggest that compared to the wild-type enzyme the majority of mutant CBS proteins are less stable in E. coli; however, we cannot exclude that some of them are also less soluble in 3% SDS.
We cannot exclude however that other, less distinct and thus less mappable elements are expressed in less tissue-specific ways across all these tissues, including the elements proximal to the expressed genes.
Although the relevance of the other reported interactions needs to be further investigated in vivo, we cannot exclude that less stable or transient interactions with frataxin could not be detected in our experimental conditions.
However, as older patients were less likely to receive salvage chemotherapy, we cannot exclude the possibility of a selection bias that excluded higher-risk elderly patients.
Yet we cannot exclude that less efficient salvage pathways mediated by Kitb and Csf1rb compensate for the loss of Kita and Csf1ra function in the mutants based on these findings.
Moreover, we cannot exclude that other less frequent non-coding variants not properly tagged by the current GWAS technology may be correlated to the MC4R coding variants.
