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It is designed to assess the effect of linagliptin compared with glimepiride, in addition to standard of care, on CV events in adults with relatively early T2D at increased CV risk or established CV complications and with less than optimized glycaemic control.
It was designed to assess the effect of empagliflozin (10 mg or 25 mg once daily) compared with placebo, in addition to standard of care, on CV events in adults with T2DM at high risk of CV events and with less than optimized glycemic control.
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The gold volume of the optimized hollow nanosphere, that may be crucial for the manufacturing cost, is 17×10 nm which is less than the optimized spheroid volume (similar results are obtained in the second therapeutic case: the gold part is approximatively 14×10 nm v.s. 24×10 for spheroid, 16×10 nm for capped cylinder and 13 ×10 nm for cylinder).
The fact that the lifetime after annealing is one order of magnitude less than for optimized GaInNAs and less than what has been published for GaInNAsSb indicates that there is still room for further optimization for GaNAsSb growth and annealing parameters.
The final shape optimization step consumes 10% of the CPU time, retaining less than 0.6% of optimized conformer pairs as neighbor pairs.
The average click-count with optimization was 1.46 clicks less than the non-optimized system for image retrieval.
The reduction with the optimized TMFD system is less than the reduction with optimized MTMFD (consisting of five TMFD units) system distributed at 2 and 5 m interval.
Our analysis explores the cost-effectiveness of systematically optimized (SO, 3 times a year) vs. non-systematically optimized (NSO, less than 3 times a year) CRT, whatever the echo optimization method used (manual or SonR® automatic).
According to Figure 7, the AR-0.73 shape Tanimoto is, on average, 0.01 less than that resulting from an optimized alignment using ROCS.
Moreover, our simulations show a variation of the current less than 30% respect to the optimized case, keeping the same shape of the I/V curve.
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