With this novel approach, advantages of mini-systems such as less systemic inflammatory response are preserved and disadvantages such as excessive subzero pressures and gaseous microemboli can be avoided.
In conclusion, in this tumour model system, fractionated RIT causes less systemic toxicity, but is also less effective at treating tumours.
It would be anticipated that, due to its unique design, this delivery system (which may be viewed as a macromolecular prodrug) would have less systemic toxicity.
The 12 'places to intervene in a system' are usually presented in an inversely numbered way (ordered from the less systemic to the more systemic).
Agree that the pharmacological principle is: local acting preparations at lower doses give less systemic adverse effects.
Certain matrix metalloproteinase inhibitors appear ineffective, but later generation inhibitors with less systemic toxicity continue to be investigated.
Nap-SLN8 showed an increase in the concentration of naproxen in the skin layer with less systemic absorption.
It could also involve ring-fencing important bits of the bank, like those that take deposits or process payments, while declaring less systemic parts insolvent.
But as Western policymakers would now wearily agree, less debt means less systemic risk for the banks if and when the property cycle turns.
Catheter-directed thrombolysis (CDT) was introduced for rapid removal of thrombi and salvage of venous valves with less systemic thrombolytic effect, and is being offered to selected patients with iliofemoral DVT to prevent development of PTS.
Thus, consistent with the design goal for this drug, and despite being less potent than CBDCA, AP5280 produced less systemic toxicity relative to its antitumour activity and thus has a greater therapeutic index.
