Sentence examples for less suppressive from inspiring English sources

We also showed that in vitro, iNOS−/− MSCs were less suppressive than wt MSCs.

We and others have demonstrated that Tregs were present and functional in cord blood mononuclear cells [3] [4], [9], though less suppressive compared to adult peripheral blood mononuclear cells (PBMC) [3].

While the frequency of neutrophil-like MDSCs was unchanged, these cells were less suppressive when extracted from C5a-producing tumors.

In the case of the WT1 promoter, N-WT1 had significantly less suppressive effect when compared with the ZF constructs.

When challenged with strain-matched Teff, B6.SLE Treg were less suppressive compared with B6 Treg (figure 4A,B).

These findings suggest that α-TEA treatment created a less suppressive tumor microenvironment that allowed effector T cells to better eliminate tumor cells.

Knockdown of UXT expression in Treg cells results in a less-suppressive phenotype, demonstrating that UXT is an important regulator of the suppressive actions of Treg cells.

Randomized trials are required to evaluate if the HLH-94 protocol is helpful or harmful compared to this less immune suppressive and cytotoxic approach in this specific population.

In parallel, the level of IFNγ, which reflected T-cell proliferation, showed a decrease in the MLR proportionally in the presence of MPCs isolated from both tissues, but to a significantly lower extent with T-MPCs, supporting a less potent suppressive activity of these cells.

Despite the fact that rhAFP and rhAFP0 demonstrated slightly less effective tumor suppressive activity as compared to eAFP but rhAFP0 had produced statistically notable increase in its ability to induce inhibition of in vitro lymphocyte proliferation as compared to the glycosylated rhAFP and eAFP.

The best understood immunosuppressive strategies include inhibition of protein kinase R (PKR) by the viral NS5A and E2 proteins, cleavage of cellular signal transduction molecules downstream of the pathogen RNA sensors RIG-I and TLR3 by the NS3/4A protein, and altering IL12 production through secretion of the core protein; other less thoroughly characterized suppressive activities also exist.