Few of the populations in these studies were restricted to atopic subjects, much less to those sensitized to any fungi, specific fungal genera, or dust mites.
Another positive note is the less sensitivity to PLK1 depletion of cells with a functional p53 [151], [151], and can help to sensitize cells to chemotherapy (as observed in lung cancer [152]).
As opposed to Opa1 −/− MEFs, Mfn1 −/− cells were even less sensitive than their wt counterpart to heat treatment (Fig. 3B), indicating that a fragmented mitochondrial network does not per se sensitize to heat shock.
Conversely, adolescents with higher serum PFNA were less likely to be sensitized to food allergens.
Strikingly, mocetinostat had no further drug-sensitizing effect in hPaca2 with already high endogenous miR-203 and miR-200, and low ZEB1 (Fig 4C and Table 2), indicating that if ZEB1 is not expressed and both microRNAs are already present, mocetinostat is less effective in sensitizing to gemcitabine.
Sensitized pathways are more excitable and less inhibited than normal pathways, resulting in increased neuronal firing [17].
Indeed, our experiments testing T cell responses showed that SHIP-1−/− splenocytes isolated from OVA sensitized and challenged mice were much less responsive to OVA antigen stimulation in IL-4 production compared to WT cells.
Jonathan Samet, the director of the Institute for Global Health and an expert on the hazards of smoke, made an intriguingpoint: the less cigarette smoke people are exposed to, the more sensitized they become to it.
We did not observe significant antibody responses to the SF-PPD proteins of molecular weights less than 20 kDa in M. bovis infected or sensitized cattle sera.
The spleen removes erythrocytes that are less deformable, such as parasite-infected cells [2], and those sensitized by IgG [3] during acute falciparum malaria.
The impression could be wrong, but the detective, sensitized to those responses, notices them more and pays less attention to others — an instance of confirmation bias.
