Furthermore, we hypothesize that CBT will be cost-effective, especially related to less expected relapse rates in comparison with pharmacological treatment.
These authors performed a meta-analysis of the three randomized trials, which suggested that, compared with daily CYC, intermittent CYC was less likely to fail to induce remission and was less toxic, but was associated with a higher relapse rate.
While current therapies in MS predominantly target inflammation and reduce relapse rate they have been less effective at preventing long-term disability.
Surgery represents the only curative option for these patients in less than 25% of the cases and the relapse rate is high (de Groen et al, 1999).
There is currently no data to support more intense regimens over less toxic regimens in terms of disease remission or relapse rate.
Consequently, patients with co-morbid substance abuse have a higher rate of re-hospitalisation, reduced psychosocial functions, less patient concordance with treatment, as well as a higher relapse rate than patients without such substance consumption [23].
Less intensive chemotherapy during induction was associated with an increased relapse rate and reduced RFS.
There was less leucopaenia with methotrexate, but more liver dysfunction and a higher relapse rate.
Although less favourable tumours initially respond well to induction chemotherapy therapy, the relapse rate is high, with relapse disease usually refractory to further treatment.
Conventional RIC allogeneic HSCT has the benefit of less immediate TRM than high dose conditioning regimens at the cost of a higher relapse rate.
