We found that expression of Slc25a20 was only slightly elevated after acute treatment with WY14643, EPA, and DHA, which indicates that the regulation of Slc25a20 by PPARα may be of less relevance during (nutritional) activation of PPARα.
Any observed adverse outcomes associated with LABA monotherapy were caused by "masking of inflammation" rather than a toxic effect of the drugs, and such concerns are of less relevance in COPD where the pattern of inflammation and the effects of ICS on this are different.
At least in macrophages the RORγt transcription factor appears to be of less relevance for expression of IL-17 s as opposed to many reports describing the role of RORγt for Th17 cell differentiation and activation [6, 16].
After effective chemotherapeutic treatment the additional influence of dietary changes was of less relevance.
These treatment options are of less relevance since the emergence of azithromycin as an effective treatment for yaws.
From a practical perspective, the mechanisms are of less relevance, though classical notions of fatigue would suggest an inability to perform at required exercise intensities precedes a decline in movement and possibly stroke play outcomes.
"We may share history and language, but the Americans have been unsentimentally clear that we are of less relevance to them if we are less important in Brussels, Berlin or Paris," he will say.
"Is America, Uncle Sam, going to help us out when we've cut ourselves off from our own European backyard?" he will say before adding "Of course not – we may share history and language, but the Americans have been unsentimentally clear that we are of less relevance to them if we are less important in Brussels, Berlin or Paris".
In this study we found no association between the time spent interacting with a latrine on the homestead of origin and the T.solium status of the pig, which we believe suggests that the presence or absence of a latrine in an individual home is of less relevance to parasite transmission than overall provision of sanitation for the wider community in which the pig roams.
This is of less relevance when considering the use of these equations to support cost-effectiveness analyses because it is the incremental difference in event rates (typically driven by risk factors reported in randomized clinical trials) that is important.
