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In the central portion at 4 weeks (Fig. 3), group 1 (control, Fig. 3a) seemed to have less newly formed bone and connective tissue compared to group 2 (Fig. 3b) and group 3 (Fig. 3c).
The weaker fluorescence on the patches suggests that these regions contain less newly synthesized proteins than the ECM bound on the substrate.
Comparing the abundance of DNA nascent strand, a significant less newly replicated DNA at FRA3B than in the nonfragile regions has been detected.
However, much thinner cortical bone and less newly formed trabecular bone were found in the distracted callus taken from group R. The trabecular bone in group I presented with more robust and regulated spatial conformation.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com