Today, Africa has less large-scale commercial agriculture than it had 50 years ago.
And there is less large-scale corruption because there are fewer lucrative investments in Indonesia's slumping economy.
Clearly there's been less large-scale construction, but also I am very satisfied that the industry has heard us and responded.
Well-known scaled agile frameworks such as SAFe (Scaled Agile Framework) and LeSS (Large-Scale Scrum) provide some directions, but not a complete answer.
We may see less large-scale trade agreements, but I don't think protectionism will resurface.
Because borders determined for the model system are strongly fluctuating (maps in Fig. 3e), they yield much less coherent large scale patches.
That requires an entirely different business model and skill set from current practices and will be less related to large scale power generation, for instance, and more about micro-managing energy networks.
Further, none of the previously mentioned databases has an open application programming interface (API) for direct consumption in scripts and third party applications, making them less useful for large scale modeling [26 29].
Mice carrying null mutant HSF1 genes or expressing a dominant-negative HSF1 are attractive model systems, because the mouse brain closely resembles the human brain; however, small offspring and high costs make rodents less attractive for large scale studies.
We tried to identify common properties of our identified RNAi targets, because this information might help identifying novel RNAi targets in species less amenable to large scale screens.
Other actions such as the choice of a pre-adapted seed source for plant community restoration or a pest control strategy that prevents resistance evolution can be implemented locally with less need for large scale coordination.
